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Bradley E. Aouizerat, PhD
Assistant Professor
Dept. of Physiological Nursing
2 Koret Way, #N-631, Box 0610
San Francisco, CA 94143-0610
Phone: 415-476-9534 Fax: 415-476-8899
Email: bradley.aouizerat@nursing.ucsf.edu
My program of research is centered on understanding the quantitative genetics (genomics) of common human disease. Moreover, I am interested in accelerating the translation of discoveries in basic science genetics (the bench) to clinical practice (the bedside).
Of particular interest to my lab is the role of common genetic variations in dyslipidemia, a risk factor for both cardiovascular diseases. Currently, we are investigating four clinical populations with discrete cardiovascular diseases: familial combined hyperlipidemia, hypoalphalipoproteinemia, hyperalphalipoproteinmia and normolipidemic controls. In addition, my lab investigates the impact of these same genetic variants on insulin resistance-related phenotypes, such as diabetes, obesity and non-alcoholic steatohepatitis.
As of 2004, we have expanded our research endeavors in partnership School of Nursing faculty who are leaders in the field of cancer (Christine Miaskowski and Marylin Dodd), HIV/AIDS (Carmen Portillo) and sleep disorders (Kathryn Lee). (More information is available at the Genetics/Genomics Research page.)
I am currently involved in teaching courses in genetics and genomics centered around: basic genomic science; the application of genomic risk assessment and testing; pharmacogenetics, the application of genetically engineered therapeutic modalities. I currently teach Biomarkers II, an Advanced Practice Seminar (N240.02), which addresses biomarkers in both health and disease with a particular focus on the use of gene-based biomarkers. In addition, I am the instructor for a Genomics specialty seminar (N294E) on Current Topics in Genetics and Genomics.
Member of the American Heart Association
Sam and Rose Gilbert Fellowship, University of California Los Angeles (1998-1999)
Warsaw Fellowship, University of California Los Angeles (1998-1999)
Postdoctoral Fellowship, Training Grant in Genetics,
Cardiovascular Research Institute, University of California, San Francisco
American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology Council
Irvine Page Young Investigator Award Finalist (2004)
American Liver Foundation National Liver Scholar (2004)
University of California Los Angeles, BS,
Microbiology and Molecular Genetics
University of California Los Angeles, Ph.D.,
Microbiology, Molecular Genetics and Immunology
University of California San Francisco, Postdoctoral Fellow,
Cardiovascular Research Institute
New! Search PubMed for publications by this author.
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Aouizerat BE, Allayee H, Bodnar J, Krass K, Peltonen L, de Bruin TWA, Rotter JI, Lusis AJ. Novel Genes for Familial Combined Hyperlipidemia. Current Opinions in Lipidology 1999; 10: 113-122.
Aouizerat BE, Allayee H, Cantor RM, Dallinga-Thie GM, Lanning CD, deBruin TWA, Lusis AJ, Rotter JI. Linkage of a candidate gene locus to familial combined hyperlipidemia:lecithin:cholesterol acyltransferase on 16q. Arteriosclerosis, Thrombosis and Vascular Biology 1999; 19: 2730-2736.
Aouizerat BE, Allayee H, Cantor RM, Davis RC, Lanning CD, Wen PZ, Dallinga-Thie GM, deBruin TW, Rotter JI, Lusis AJ. A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. American Journal of Human Genetics 1999; 65: 397-412.
Aouizerat B, Kulkarni K, Heilbron D, Drown D, Raskin S, Pullinger C Malloy M, Kane J. The Effect of Variation within the Human Apolipoprotein A-V Gene on Plasma Lipids. Journal of Lipid Research, 2003, 44: 1167-1173
Wung S-F & Aouizerat BE. Gender And Ethnic Differences In Cardiovascular Genetics: Using Apolipoprotein V Gene As An Exemplar. Research and Theory for Nursing Practice, 2003, 17: 281-299.
Aouizerat BE & Kane JP. Apolipoprotein A-II: active or passive role in Familial Combined Hyperlipidemia. Circulation Research. 2003 Jun 13; 92(11): 1179-81.
Wung S-F & Aouizerat BE. The Newly Mapped Gene for Thoracic Aortic Aneurysm and Dissection. Journal of Cardiovascular Nursing (in press).
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